Print

Purpose

The primary goals of this study are to examine 1) marijuana modulation of oxycodone self-administration and 2) oxycodone modulation of marijuana self-administration, under controlled conditions and across a range of doses for each drug.

Conditions

Eligibility

Eligible Ages
Between 18 Years and 50 Years
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Ages 18-50 - Experience with marijuana and opioids - General good health - Willing to live at the University of Kentucky Hospital (research unit) for approx. 6.5 weeks (meals are provided,

Exclusion Criteria

  • Significant medical complications/conditions

Study Design

Phase
Phase 1
Study Type
Interventional
Allocation
Randomized
Intervention Model
Crossover Assignment
Primary Purpose
Basic Science
Masking
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Double-blind marijuana/placebo administration 		Participants will receive double-blind administration of vaporized marijuana/placebo
  • Drug: Marijuana
    Double-blind administration of marijuana
    Other names:
    • Cannabis
  • Drug: Opioid
    Double-blind administration of an opioid agonist
Experimental
Double-blind opioid/placebo administration 		Participants will receive double-blind administration of intranasal opioid agonist/placebo
  • Drug: Marijuana
    Double-blind administration of marijuana
    Other names:
    • Cannabis
  • Drug: Opioid
    Double-blind administration of an opioid agonist

Recruiting Locations

UK Center for Clinical and Translational Science and nearby locations

University of Kentucky
Lexington, Kentucky 40506
Contact:
Paul Nuzzo
859-323-0002
pnuzz2@email.uky.edu

More Details

NCT ID
NCT05485012
Status
Recruiting
Sponsor
Shanna Babalonis, PhD

Study Contact

Paul Nuzzo
(859) 323-0002
pnuzz2@email.uky.edu

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.