Reinforcing Effects of Marijuana and Opioids

Purpose

The primary goals of this study are to examine 1) marijuana modulation of oxycodone self-administration and 2) oxycodone modulation of marijuana self-administration, under controlled conditions and across a range of doses for each drug.

Conditions

  • Marijuana Use
  • Opioid Use

Eligibility

Eligible Ages
Between 18 Years and 50 Years
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Ages 18-50 - Experience with marijuana and opioids - General good health - Willing to live at the University of Kentucky Hospital (research unit) for approx. 6.5 weeks (meals are provided,

Exclusion Criteria

  • Significant medical complications/conditions

Study Design

Phase
Phase 1
Study Type
Interventional
Allocation
Randomized
Intervention Model
Crossover Assignment
Primary Purpose
Basic Science
Masking
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Double-blind marijuana/placebo administration 		Participants will receive double-blind administration of vaporized marijuana/placebo
  • Drug: Marijuana
    Double-blind administration of marijuana
    Other names:
    • Cannabis
  • Drug: Opioid
    Double-blind administration of an opioid agonist
Experimental
Double-blind opioid/placebo administration 		Participants will receive double-blind administration of intranasal opioid agonist/placebo
  • Drug: Marijuana
    Double-blind administration of marijuana
    Other names:
    • Cannabis
  • Drug: Opioid
    Double-blind administration of an opioid agonist

Recruiting Locations

UK Center for Clinical and Translational Science and nearby locations

University of Kentucky
Lexington, Kentucky 40506
Contact:
Paul Nuzzo
859-323-0002
pnuzz2@email.uky.edu

More Details

NCT ID
NCT05485012
Status
Recruiting
Sponsor
Shanna Babalonis, PhD

Study Contact

Paul Nuzzo
(859) 323-0002
pnuzz2@email.uky.edu