Search Clinical Trials
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Neurobehavioral Mechanisms of Choice in Opioid Use Disorder
Joshua A. Lile, Ph.D.
Opioid Use Disorder
The objective of this protocol is to use probabilistic reinforcement learning choice tasks
and magnetic resonance neuroimaging to demonstrate the impact of problematic opioid use and
opioid withdrawal on dynamic decision-making and reveal the neurobehavioral and
neurobiological... expand
The objective of this protocol is to use probabilistic reinforcement learning choice tasks and magnetic resonance neuroimaging to demonstrate the impact of problematic opioid use and opioid withdrawal on dynamic decision-making and reveal the neurobehavioral and neurobiological processes underlying abnormal task performance. A second objective is to identify an appropriate dose of intravenous remifentanil for subsequent studies in physically dependent individuals with opioid use disorder. Type: Interventional Start Date: Aug 2019 |
STABILITY 2: Anterior Cruciate Ligament Reconstruction +/- Lateral Tenodesis With Patellar vs Quad Tendon
University of Pittsburgh
Anterior Cruciate Ligament Injury
Anterior Cruciate Ligament Reconstruction
Joint Instability
Anterior cruciate ligament (ACL) rupture is one of the most common musculoskeletal injuries
in young individuals, particularly those that are active in sports. Up to 30% of individuals
under the age of 20 years suffer a re-injury to the reconstructed ACL. Revision ACLR has been... expand
Anterior cruciate ligament (ACL) rupture is one of the most common musculoskeletal injuries in young individuals, particularly those that are active in sports. Up to 30% of individuals under the age of 20 years suffer a re-injury to the reconstructed ACL. Revision ACLR has been associated with degeneration of the articular cartilage and increased rates of meniscal tears, increasing the risk of post-traumatic osteoarthritis (PTOA), additional surgical procedures, reduced physical function and quality of life. As such, strategies to reduce ACLR failure, particularly in young active individuals, are critical to improving short and long-term outcomes after ACL rupture. There is ongoing debate about the optimal graft choice and reconstructive technique. Three autograft options are commonly used, including the bone-patellar-tendon-bone (BPTB), quadriceps tendon (QT) and hamstring tendon (HT). Additionally, a lateral extra-articular tenodesis (LET) may provide greater stability to the ACLR; however, its effect on failure rate is unclear and surgery-induced lateral compartment OA is a concern. To definitively inform the choice of autograft and the need for a LET, this multicenter, international randomized clinical trial will randomly assign 1236 young, active patients at high risk of re-injury to undergo ACLR using BPTB or QT autograft with our without LET. Type: Interventional Start Date: Jul 2020 |
TVB 2640 for Resectable Colon Cancer Other Resectable Cancers; a Window Trial.
Mark Evers
Colon Cancer
Primary Objective
• To evaluate the pharmacodynamic effects on metabolic endpoints (malonyl carnitine and
tripalmitin levels) following short-term treatment with TVB-2640 in patients with resectable
cancers
Secondary Objectives
- To determine if short-term... expand
Primary Objective • To evaluate the pharmacodynamic effects on metabolic endpoints (malonyl carnitine and tripalmitin levels) following short-term treatment with TVB-2640 in patients with resectable cancers Secondary Objectives - To determine if short-term treatment with TVB-2640 decreases cancer cell proliferation. - To examine other biological endpoints and determine if TVB-2640 inhibits cell survival signaling and lipid biogenesis. - To perform comprehensive metabolomic analysis in tumor tissues to identify metabolic alterations induced by TVB-2640 treatment. - To correlate FASN levels in tumor with metabolic and biological endpoints to determine if FASN inhibition has more pronounced effects in patients with increased expression. Type: Interventional Start Date: Oct 2017 |
Behavioral Effects of Drugs (Inpatient): 43 (Opioids, Cocaine, n-Acetylcysteine)
William Stoops
Cocaine Use Disorder
Opioid Use Disorder
The overarching hypotheses of this protocol are that (1) persistent brain glutamate changes
induced by chronic opioid use will exacerbate use of cocaine during opioid physical
dependence and withdrawal and (2) n-acetylcysteine (NAC) will ameliorate glutamatergic
dysregulation,... expand
The overarching hypotheses of this protocol are that (1) persistent brain glutamate changes induced by chronic opioid use will exacerbate use of cocaine during opioid physical dependence and withdrawal and (2) n-acetylcysteine (NAC) will ameliorate glutamatergic dysregulation, and thus will reduce both opioid and cocaine demand. These hypotheses will be tested with two specific aims. Specific Aim 1. Determine the reinforcing effects of cocaine in individuals with comorbid opioid and cocaine use disorder with physiological dependence on opioids during NAC maintenance. All subjects will be maintained on oral hydromorphone. They will also be randomly assigned to receive placebo or oral NAC (2.4 g/day), stratified by sex. After dose stabilization, experimental sessions will be conducted in which subjects complete hypothetical cocaine purchase tasks during opioid maintenance and opioid withdrawal. The hypotheses are: 1) cocaine purchasing will be greater during opioid withdrawal and 2) NAC maintenance will attenuate cocaine purchasing across opioid maintenance and withdrawal periods. Specific Aim 2. Evaluate glutamate functionality during periods of opioid maintenance and withdrawal in individuals with comorbid opioid and cocaine use disorder and physiological dependence on opioids during NAC maintenance. Subjects will undergo magnetic resonance spectroscopy to evaluate brain glutamate changes as a function of opioid maintenance/withdrawal state and NAC maintenance. The hypotheses are: 1) glutamate levels will be elevated during opioid withdrawal and 2) NAC maintenance will ameliorate elevated glutamate levels. Type: Interventional Start Date: Dec 2022 |
Muscle Recovery After Critical Illness
Kirby Mayer
ICU Acquired Weakness
Post Intensive Care Unit Syndrome
Muscle Weakness
Critical Illness
The overarching goal of the proposed study is to determine the trajectories of physical
recovery and cellular markers involved with the underlying failure to recover muscle after
critical illness, while exploring which characteristics are associated with sustained
physical... expand
The overarching goal of the proposed study is to determine the trajectories of physical recovery and cellular markers involved with the underlying failure to recover muscle after critical illness, while exploring which characteristics are associated with sustained physical disability. This proposal will examine muscle pathophysiology carefully aligned with physical function outcomes in order to longitudinally assess the recovery, or failed recovery, of muscle function in participants after critical illness: 1. to examine the recovery of muscle and physical function in ICU survivors through longitudinal assessments 2. to investigate the underlying cellular markers and mechanisms of muscle recovery in ICU survivors 3. to determine which cellular markers contribute to physical disability in ICU survivors up to 1 year after hospital admission Type: Observational Start Date: Oct 2022 |
tDCS and Inhibitory Control in PTSD
University of Kentucky
Post Traumatic Stress Disorder
Large samples (~2,000/yr) of adult undergraduate students at a large southern university will
be pre-screened via the University of Kentucky SONA System (IRB#43626) to identify and
recruit adult female participants who report a history of IPV and probable PTSD to
participate... expand
Large samples (~2,000/yr) of adult undergraduate students at a large southern university will be pre-screened via the University of Kentucky SONA System (IRB#43626) to identify and recruit adult female participants who report a history of IPV and probable PTSD to participate in a one-day lab study. After completing an IRB-approved informed consent, participants will complete a brief psychiatric diagnostic interview and a battery of questionnaires. They will then complete three blocks of the Stop Signal Task (SST). Participants will be randomized (double-blind, stratified by PTSD diagnosis and psychotropic medication use) to receive 15-min of active or sham multifocal tDCS targeting the rIFG. tDCS will be delivered offline for 11.5-mins after block 1 of the SST and online for 3.5-mins during block 2 of the SST. Sham stimulation will be identical to active tDCS, but electrical current will only be ramped in/out at the beginning and end of the 15-mins. The third block of the SST will be completed after tDCS. Lastly, participants will complete a pictorial trauma-related symptom provocation task. Participants will be compensated with course credit. Type: Interventional Start Date: Oct 2023 |
Induction Chemo-Nivo in Unresectable Stage III NSCLC
Ralph G Zinner
Lung Cancer, Nonsmall Cell
Lung Cancer Stage III
The purpose of this study is to determine the response rate, safety, and effectiveness of a
combination therapy in patients with lung cancer.
expand
The purpose of this study is to determine the response rate, safety, and effectiveness of a combination therapy in patients with lung cancer. Type: Interventional Start Date: Sep 2023 |
Feasibility and Safety of autoloGous UncondItioneD pEripheral Nerve Tissue Delivery to the Substantia...
Craig van Horne, MD, PhD
Parkinson's Disease
This is an open-label, non-randomized, single-arm trial design to actively follow
participants for 12 months. Ten participants will be enrolled to receive bilateral delivery
of Peripheral Nerve Tissue (PNT) to the Substantia Nigra at the time of Deep Brain
Stimulation (DBS)... expand
This is an open-label, non-randomized, single-arm trial design to actively follow participants for 12 months. Ten participants will be enrolled to receive bilateral delivery of Peripheral Nerve Tissue (PNT) to the Substantia Nigra at the time of Deep Brain Stimulation (DBS) surgery. After 12 months, participants will be followed long term through annual visits for the rest of their lives. Participants will serve as their own donor for the tissue. Type: Interventional Start Date: Jul 2022 |
Reinforcing Effects of Marijuana and Opioids
Shanna Babalonis, PhD
Marijuana Use
Opioid Use
The primary goals of this study are to examine 1) marijuana modulation of oxycodone
self-administration and 2) oxycodone modulation of marijuana self-administration, under
controlled conditions and across a range of doses for each drug.
expand
The primary goals of this study are to examine 1) marijuana modulation of oxycodone self-administration and 2) oxycodone modulation of marijuana self-administration, under controlled conditions and across a range of doses for each drug. Type: Interventional Start Date: Aug 2023 |
Thoracic-Lumbar Arthrodesis- Implanet Jazz
H. Francis Farhadi
Spondylolisthesis
Spinal Stenosis
Degenerative Disease
Establish a data repository of patients who have undergone single, two-, or three-level
lumbar instrumented arthrodesis procedures supplemented by the Implanet Jazz System.
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Establish a data repository of patients who have undergone single, two-, or three-level lumbar instrumented arthrodesis procedures supplemented by the Implanet Jazz System. Type: Observational [Patient Registry] Start Date: Feb 2022 |
The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics
Philip Kern
Pre-diabetes
Obesity
The investigator hypothesizes that treatment with the ß3 agonist mirabegron results in
improved glucose metabolism, including a reversal of prediabetes in obese, insulin-resistant
human research participants, and this is further improved by combination therapy with
tadalafil.... expand
The investigator hypothesizes that treatment with the ß3 agonist mirabegron results in improved glucose metabolism, including a reversal of prediabetes in obese, insulin-resistant human research participants, and this is further improved by combination therapy with tadalafil. The investigator will comprehensively analyze glucose homeostasis in prediabetic patients treated for 14 weeks with mirabegron, tadalafil or both drugs as compared to a placebo. Type: Interventional Start Date: Dec 2021 |
Healthy Recovery After Trauma Study
Christal L Badour
Stress Disorders, Post-Traumatic
Shame
Guilt
Sexual Assault and Rape
Mental contamination-an internal experience of dirtiness evoked in the absence of physical
contact with an external source-has been linked to the development and maintenance of
posttraumatic stress disorder (PTSD) following exposure to sexual abuse or assault (Adams et
al.,... expand
Mental contamination-an internal experience of dirtiness evoked in the absence of physical contact with an external source-has been linked to the development and maintenance of posttraumatic stress disorder (PTSD) following exposure to sexual abuse or assault (Adams et al., 2014; Badour et al., 2013; Brake et al., 2017). Mental contamination has been associated with greater PTSD severity (Rachman et al., 2015) and higher elevations in specific PTSD symptom clusters (particularly those of intrusive reexperiencing, negative cognitions/mood, and arousal/reactivity; Brake et al., 2019; Fergus & Bardeen, 2016). Additionally, trauma-related mental contamination has been linked to a number of negative posttraumatic emotions such as shame, guilt, disgust, and anger (Fairbrother & Rachman, 2004; Radomsky & Elliott, 2009) Despite clear and consistent links between mental contamination and problematic posttraumatic outcomes following sexual trauma, there is a dearth of research investigating how existing or promising new interventions for PTSD impact mental contamination. Cognitive Processing Therapy (CPT) is an efficacious and effective 12-session manualized cognitive-behavioral intervention for PTSD that is considered a gold-standard empirically-supported treatment for PTSD that is recommended by the American Psychological Association (APA, 2017). In addition to PTSD symptom improvement, CPT has also demonstrated benefit for improving feelings of shame and guilt, which are often seen among individuals with trauma-related mental contamination (Nishith et al., 2005; Resick et al., 2002, 2008). Cognitive reappraisal, a primary technique employed in CPT, involves challenging one's view of an emotionally-eliciting situation to alter its emotional impact (Gross & John, 2003). However, some investigators have suggested that cognitive reappraisal may be less effective in targeting moral emotions such as shame, guilt, and self-disgust that are based on an individual's standards and virtues (Finlay, 2015). Self-compassion (SC; i.e., self-directed care and kindness; forgiveness; and feelings of common humanity; Neff, 2003) has been proposed as an alternative method for addressing trauma-related shame and preliminary evidence suggests a 6-session self-compassion intervention may have benefit for reducing both PTSD symptoms and trauma-related shame (Au et al., 2017). Given the centrality of shame, guilt, and self-disgust to the experience of mental contamination, and the fact that mental contamination often arises in response to experiences involving moral violation or betrayal (Millar et al., 2016; Rachman, 2010), a SC intervention for PTSD may also offer promise as a standalone or adjunctive intervention for reducing trauma-related mental contamination. A test of these interventions for their impact on reducing trauma-related mental contamination is needed. The current study will use Single Case Experimental Design to isolate and evaluate the effects of CPT and SC in reducing both PTSD symptoms and trauma-related mental contamination among individuals with PTSD resulting from sexual trauma. Aims: 1) explore whether participants demonstrate reductions in mental contamination and PTSD symptoms in response to 12-sessions of CPT or 6-sessions of a SC intervention; 2) evaluate whether presentation of either treatment first yields differences in symptom reduction for PTSD and/or mental contamination symptoms; 3) evaluate whether the addition of the alternative module will enhance reductions in PTSD symptoms and mental contamination; 4) evaluate if such reductions are maintained during follow-up. Visual inspection analysis and statistical methods will be used to draw conclusions regarding the effects of the interventions on PTSD symptoms and mental contamination. Type: Interventional Start Date: Sep 2020 |
A Study to Learn How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Compared to...
Regeneron Pharmaceuticals
Follicular Lymphoma (FL)
This study is researching an experimental drug called odronextamab, referred to as study
drug. The study is focused on participants with previously untreated follicular lymphoma in
Part 2, as well as participants with lymphoma that has come back after treatment (called
"relapsed")... expand
This study is researching an experimental drug called odronextamab, referred to as study drug. The study is focused on participants with previously untreated follicular lymphoma in Part 2, as well as participants with lymphoma that has come back after treatment (called "relapsed") or did not respond to treatment (called "refractory"), in Part 1. Follicular lymphoma is a type of non-Hodgkin lymphoma or NHL. This study is made up of 3 parts: Part 1A (non-randomized), Part 1B and Part 2 (randomized - controlled). The aim of Part 1A and Part 1B of the study is to see how safe and tolerable the study drug in combination with chemotherapy is and to determine the dose and schedule of the study drug to be combined with chemotherapy to be used in Part 2 of the study. The aim of Part 2 of the study is to assess how effective the combination of the study drug with chemotherapy is in comparison with the combination of rituximab and chemotherapy (the current standard-of-care for NHL). Standard-of-care means the usual medication expected and used when receiving treatment for a condition. The study is looking at several other research questions, including: - What side effects may happen from taking the study drug - How much study drug is in your blood at different times - Whether the body makes antibodies against the study drug (which could make the study drug less effective or could lead to side effects) - The impact from the study drug on your quality-of-life and ability to complete routine daily activities Type: Interventional Start Date: Nov 2023 |
Person-Environment Fit for Persons With Dementia
Elizabeth K Rhodus
Dementia Alzheimers
Alzheimer Disease
This trial will assess feasibility of a non-pharmacological intervention for persons living
with Alzheimer's disease and related dementias (ADRD) to improve behavioral and psychiatric
symptoms of dementia and functional performance.
Using a two-arm, prospective randomized... expand
This trial will assess feasibility of a non-pharmacological intervention for persons living with Alzheimer's disease and related dementias (ADRD) to improve behavioral and psychiatric symptoms of dementia and functional performance. Using a two-arm, prospective randomized controlled trial, 38 dyads (person with ADRD and caregiver) will complete an 8-week telehealth occupational therapy intervention provided via Zoom with caregivers and persons with dementia or receive an active control with 8 telehealth sessions to discuss publicly available caregiver education with a non-clinical research assistant. Type: Interventional Start Date: Jun 2023 |
Pain and Activity Levels After Orthodontic Separators
Lina Sharab
Dental Malocclusion
The primary aim of this study is to evaluate the reported pain intensity following placement
of Orthodontic separators on healthy volunteers aged 18-49 in relation to their recorded
physical activity level.
Hypothesis 1: The investigators hypothesize that participants with... expand
The primary aim of this study is to evaluate the reported pain intensity following placement of Orthodontic separators on healthy volunteers aged 18-49 in relation to their recorded physical activity level. Hypothesis 1: The investigators hypothesize that participants with higher daily step counts and physical activity levels will report significantly less pain intensity from orthodontic separators than their less active peers following separator placement. Null hypothesis is that participants with higher daily step counts will report the same pain intensity from orthodontic separators than their less active peers following separator placement The secondary aim is to describe the course of pain, at 24 hr intervals, over the next seven days following separator placement. Hypothesis 2: The investigators hypothesize that more physically active participants will report ratings of zero pain intensity faster (sooner) than their less active peers throughout the one week study. Secondary null hypothesis is that more physically active participants will report ratings of zero pain intensity at the same rate as their less active peers throughout the one week study. Type: Interventional Start Date: Jul 2022 |
Rehabilitation Strategies to Improve Outcomes For Patients With a Lower Extremity Fracture
Brian W. Noehren
Femoral Fracture
Tibial Fractures
The purpose of this study is to evaluate speed high intensity interval training (HIIT)
walking program following an orthopedic trauma.
expand
The purpose of this study is to evaluate speed high intensity interval training (HIIT) walking program following an orthopedic trauma. Type: Interventional Start Date: Mar 2022 |
Telehealth Delivered Physical Rehabilitation for an Ankle Sprain
Kyle Kosik
Ankle Sprains
Telerehabilitation
Analgesic, Opioid
Analgesics, Non-narcotic
Anti-Inflammatory Agents, Non-Steroidal
A vast majority (75-85%) of ankle sprain patients treated in emergency departments (ED)
receive pain medication and are not referred for physical rehabilitation. Therefore, purpose
of this study is to increase access to the standard of care for an ankle sprain by provide
patients... expand
A vast majority (75-85%) of ankle sprain patients treated in emergency departments (ED) receive pain medication and are not referred for physical rehabilitation. Therefore, purpose of this study is to increase access to the standard of care for an ankle sprain by provide patients with physical rehabilitation delivered through telehealth. The purpose of this study includes compare a 2-week telehealth intervention to the usual care for treating 1) subjective function; 2) physical impairments; 3) medication consumption; and 4) patient-perceived barriers. The central hypothesis is participants receiving the 2-week telehealth intervention will 1) have less pain and disability; 2) improve balance and ankle range of motion; 3) consume less medication; and 4) reports positive feedback compared to the usual care group. Type: Interventional Start Date: Jan 2021 |
Novel Precision Medicine Approach to Treatment of Osteoporosis Based on Bone Turnover
Hartmut Malluche, MD
Age-Related Osteoporosis
Osteoporosis affects 24.5% of women over 65 and results in fracture-related hospital
admissions exceeding those of heart attacks, strokes and breast cancer combined. Current
treatment options do not account for differences between age-related and estrogen deficiency
related... expand
Osteoporosis affects 24.5% of women over 65 and results in fracture-related hospital admissions exceeding those of heart attacks, strokes and breast cancer combined. Current treatment options do not account for differences between age-related and estrogen deficiency related osteoporosis, because of the need for bone biopsies for determination. This study will establish a paradigm-shifting individualized treatment protocol for age-related osteoporosis and a non-invasive method for its determination, thereby reducing the major health problems and enormous burden on society and the elderly related to this disease. Type: Interventional Start Date: Mar 2022 |
Heart of the Family: A Cardiovascular Disease and Type 2 Diabetes Risk Reduction Intervention in High-Risk...
Gia Mudd
Diabetes Mellitus, Type 2
Cardiovascular Diseases
Rural populations in the U.S. are disproportionately burdened by cardiovascular disease and
type 2 diabetes. Lifestyle modification interventions are needed that support long-term
engagement in risk-reducing health behaviors. This trial will study the effects of a
family-focused,... expand
Rural populations in the U.S. are disproportionately burdened by cardiovascular disease and type 2 diabetes. Lifestyle modification interventions are needed that support long-term engagement in risk-reducing health behaviors. This trial will study the effects of a family-focused, lifestyle intervention that is culturally tailored for use with rural Hispanic and non-Hispanic adults. If successful, this community-based intervention has significant potential for broad dissemination to reduce cardiovascular disease and type 2 diabetes health disparities in rural U.S. communities. Type: Interventional Start Date: Sep 2021 |
Safety of Sildenafil in Premature Infants With Severe Bronchopulmonary Dysplasia
Christoph Hornik
Bronchopulmonary Dysplasia of Newborn
This is a multicenter, randomized, placebo-controlled, sequential dose-escalating,
double-masked, safety study of sildenafil in premature infants (inpatient in Neonatal
Intensive Care Units (NICUs)) with severe bronchopulmonary dysplasia (BPD).
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This is a multicenter, randomized, placebo-controlled, sequential dose-escalating, double-masked, safety study of sildenafil in premature infants (inpatient in Neonatal Intensive Care Units (NICUs)) with severe bronchopulmonary dysplasia (BPD). Type: Interventional Start Date: May 2021 |
Ketamine in Patients Undergoing TEVAR Procedures Receiving NCI
Anna Rockich
Descending Aortic Dissection
Postoperative Pain
Thoracoabdominal Aortic Aneurysm
The objective of this study is to identify the opioid-sparing effects, and pain-reduction
potential of low dose, sub-dissociative ketamine on patients undergoing thoracic endovascular
aortic repair (TEVAR) procedures receiving naloxone continuous infusion (NCI).
expand
The objective of this study is to identify the opioid-sparing effects, and pain-reduction potential of low dose, sub-dissociative ketamine on patients undergoing thoracic endovascular aortic repair (TEVAR) procedures receiving naloxone continuous infusion (NCI). Type: Interventional Start Date: Dec 2020 |
Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial
AtriCure, Inc.
Ischemic Stroke
Systemic Embolism
This trial is a prospective, randomized, multicenter, multinational, blinded, superiority
trial. The objective of this trial is to evaluate the effectiveness of left atrial appendage
exclusion (LAAE) for the prevention of ischemic stroke or systemic arterial embolism in
subjects... expand
This trial is a prospective, randomized, multicenter, multinational, blinded, superiority trial. The objective of this trial is to evaluate the effectiveness of left atrial appendage exclusion (LAAE) for the prevention of ischemic stroke or systemic arterial embolism in subjects undergoing cardiac surgery who have risk factors for atrial fibrillation and ischemic stroke. Type: Interventional Start Date: Jan 2023 |
Behavioral Parent Training for Families With Deaf and Hard of Hearing Preschoolers
Christina Studts
Deafness
Hearing Loss
Parenting
Child Behavior
Children who are deaf and hard of hearing (DHH) rarely receive behavioral interventions to
prevent the long-term costly outcomes of behavior problems. This project will systematically
adapt an evidence-based parent training intervention to increase its acceptability and
relevance... expand
Children who are deaf and hard of hearing (DHH) rarely receive behavioral interventions to prevent the long-term costly outcomes of behavior problems. This project will systematically adapt an evidence-based parent training intervention to increase its acceptability and relevance for parents of young DHH children. Effectiveness of the adapted intervention and its implementation with parents of young DHH children followed in "real world" hearing healthcare clinics will be assessed. Type: Interventional Start Date: Jan 2020 |
LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell...
North American Consortium for Histiocytosis
Langerhans Cell Histiocytosis
The LCH-IV is an international, multicenter, prospective clinical study for pediatric
Langerhans Cell Histiocytosis LCH (age < 18 years).
expand
The LCH-IV is an international, multicenter, prospective clinical study for pediatric Langerhans Cell Histiocytosis LCH (age < 18 years). Type: Interventional Start Date: Nov 2016 |
Testing the Use of Targeted Treatment for RET Positive Advanced Non-small Cell Lung Cancer
SWOG Cancer Research Network
Lung Non-Small Cell Carcinoma
Recurrent Lung Non-Small Cell Carcinoma
Stage IV Lung Cancer AJCC v8
Stage IVA Lung Cancer AJCC v8
Stage IVB Lung Cancer AJCC v8
This phase II Lung-MAP treatment trial tests whether carboplatin and pemetrexed with or
without selpercatinib works to shrink tumors in patients with RET fusion-positive non-small
cell lung cancer that is stage IV or has not responded to previous RET directed therapy.
Chemotherapy... expand
This phase II Lung-MAP treatment trial tests whether carboplatin and pemetrexed with or without selpercatinib works to shrink tumors in patients with RET fusion-positive non-small cell lung cancer that is stage IV or has not responded to previous RET directed therapy. Chemotherapy drugs, such as carboplatin and pemetrexed, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Selpercatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving selpercatinib in combination with carboplatin and pemetrexed may help lower the chance of the cancer growing and spreading. Type: Interventional Start Date: Jul 2022 |
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