Transcranial Magnetic Stimulation for Methamphetamine Use Disorder in PLWH
Purpose
The purpose of this study is to learn more about how accelerated theta burst stimulation affects methamphetamine craving and brain activity. Theta burst stimulation is a unique transcranial magnetic stimulation (TMS) paradigm that is efficient and potent.
Conditions
- Methamphetamine Use Disorders
- HIV
Eligibility
- Eligible Ages
- Between 18 Years and 65 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Adults in the age group 18-65 years - Able to read and understand English - Able to provide informed consent - Diagnosed with HIV - History of current or previous Methamphetamine Use Disorder - Endorse craving for methamphetamine - Demonstrate an attentional bias for methamphetamine
Exclusion Criteria
- Traumatic brain injury - h/o seizure disorder - h/o or current diagnosis of schizophrenia - intracranial metal shrapnel - previous adverse effects with TMS - sub-threshold consistency while performing behavioral tasks - lack of attentional bias to methamphetamine cues - a positive pregnancy test for female participants
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Intervention Model Description
- Within participant design with a randomized sequence of interventions.
- Primary Purpose
- Treatment
- Masking
- Single (Participant)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Other Group 1 |
Group 1 will receive actual TMS (iTBS and cTBS) on days 2 and 3 and sham TMS on day 4. |
|
|
Other Group 2 |
Group 2 will receive actual TMS (iTBS and cTBS) on days 2 and 4 and sham TMS on day 3. |
|
|
Other Group 3 |
Group 3 will receive sham TMS on day 2 and actual TMS (iTBS and cTBS) on days 3 and 4. |
|
Recruiting Locations
UK Center for Clinical and Translational Science and nearby locations
Lexington, Kentucky 40509
More Details
- NCT ID
- NCT06830980
- Status
- Recruiting
- Sponsor
- Gopalkumar Rakesh
Detailed Description
The investigators will compare how two theta burst paradigms, intermittent theta burst stimulation (iTBS) and continuous theta burst stimulation (cTBS), compare with sham TMS in changing methamphetamine craving and brain activity. iTBS, cTBS, and sham TMS will be delivered in an accelerated fashion (two sessions daily, separated by 50 minutes). iTBS will be delivered to the left dorsolateral prefrontal cortex (left dorsolateral prefrontal cortex), and cTBS will be delivered to the frontal pole. A brain MRI scan will be done before and after the iTBS/cTBS/sham TMS sessions. The study involves four visits. Each visit will last three hours. Hence, participants will spend a total of 12 hours in the study.