UK Center for Clinical and Translational Science

Eligibility

Eligible Ages

Between 21 Years and 55 Years

Eligible Genders

All

Accepts Healthy Volunteers

Yes

Criteria

Inclusion/Exclusion Criteria:

1. Able to speak and read English.

2. Not seeking treatment at the time of the study.

3. Between the ages of 21 and 55 years.

4. Engaging in at least one binge drinking episode, per the NIAAA definition, in the
last 30 days.

5. Fulfillment of moderate or severe DSM-5 diagnostic criteria for AUD based on
computerized SCID results reviewed by a psychiatrist or psychologist.

6. ECG, read by cardiologist, within normal limits.

7. Body mass index of 19 - 35.

8. Birthing individuals using an effective form of birth control and not pregnant or
breast feeding.

9. Judged by the medical staff to be psychiatrically and physically healthy (i.e., no
current severe SUD or psychiatric diagnoses other than AUD or Tobacco Use Disorder;
no current physical diagnoses that would interfere with study participation
according to study physician judgment).

10. Not currently physiologically dependent on any substances.

11. Able to abstain from alcohol during admission (i.e., not physically dependent on
alcohol and scores less than 8 on Clinical Institute Withdrawal Assessment for
Alcohol [CIWA-Ar] at screening).

12. Not currently taking any prescribed medications for a chronic condition (other than
birth control).

13. No indication of sleep apnea on the STOP-Bang questionnaire (score of 5 or greater).

14. No contraindications/allergies to suvorexant.