International Spontaneous Coronary Artery Dissection (SCAD) "iSCAD" Registry
Purpose
The aim of "iSCAD," the International Spontaneous Coronary Artery Dissection (SCAD) Registry, is to serve as an internationally collaborative, multicenter registry coordinated by an experienced and centralized coordinating center in an effort to increase the pace of participant recruitment, and thereby increase statistical power of studies related to SCAD. The ultimate goal of iSCAD Registry is to facilitate the development of best practices and clinical guidelines for preventing SCAD or its recurrence. This observational study will be prospective and retrospective in its recruitment and will collect clinical information to better understand the natural history and prognosis for SCAD.
Condition
- Spontaneous Coronary Artery Dissection
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
Participants with a new diagnosis of SCAD or a history of confirmed or suspected SCAD will be prospectively recruited from either: 1. Inpatient wards of the enrolling medical centers during the acute presentation of SCAD, or 2. Outpatient cardiovascular clinics of enrolling medical centers. Participants must be: - 18 years of age or older - Diagnosis of SCAD or history of SCAD based on coronary angiography, either catheter-based or coronary CTA - Suspected SCAD by coronary angiography
Exclusion Criteria
- Coronary dissection in association with atherosclerosis or as a result of iatrogenic injury 2. Inability to provide informed consent 3. Inability to complete study-related patient questionnaires 4. Inability to understand and complete patient questionnaires independently
Study Design
- Phase
- Study Type
- Observational [Patient Registry]
- Observational Model
- Cohort
- Time Perspective
- Other
Recruiting Locations
Los Angeles 5368361, California 5332921 90048
Los Angeles 5368361, California 5332921 93003
San Francisco 5391959, California 5332921 94115
Aurora 5412347, Colorado 5417618 80045
Hartford 4835797, Connecticut 4831725 06106
Tampa 4174757, Florida 4155751 33602
Atlanta 4180439, Georgia 4197000 30308
Chicago 4887398, Illinois 4896861 60611
Baltimore 4347778, Maryland 4361885 21224
Boston 4930956, Massachusetts 6254926 02114-2696
Kansas City 4393217, Missouri 4398678 64111
Lebanon 5088597, New Hampshire 5090174 03756
Manchester 5089178, New Hampshire 5090174 03102
New York 5128581, New York 5128638 10029-6574
New York 5128581, New York 5128638 10032
Charlotte 4460243, North Carolina 4482348 28204
Cleveland 5150529, Ohio 5165418 44106
Portland 5746545, Oregon 5744337 97225
Philadelphia 4560349, Pennsylvania 6254927 19104
Pittsburgh 5206379, Pennsylvania 6254927 15212
Pittsburgh 5206379, Pennsylvania 6254927 15213
Nashville 4644585, Tennessee 4662168 37232
Dallas 4684888, Texas 4736286 75390
Murray 5778755, Utah 5549030 84107
Charlottesville 4752031, Virginia 6254928 22908
Fairfax 4758023, Virginia 6254928 22031
Seattle 5809844, Washington 5815135 98195
More Details
- NCT ID
- NCT04496687
- Status
- Recruiting
- Sponsor
- SCAD Alliance
Detailed Description
Spontaneous Coronary Artery Dissection (SCAD) is an under-diagnosed cause of acute coronary syndrome (ACS), myocardial infarction (MI) and sudden cardiac arrest. The inner lining of the coronary artery splits and allows blood to seep into the adjacent layer, forming a blockage (hematoma), or the artery continues to tear, creating a flap of tissue that blocks blood flow in the artery. SCAD strikes generally healthy, younger individuals (average age 42) who do not have traditional cardiac risk factors. Warning signs of SCAD encompass the full range of ACS and MI symptoms, from vague to classic. The cause of SCAD is currently unknown and the psychosocial impact of SCAD is traumatizing. The work of the iSCAD Registry will encompass the physical and psychosocial study of SCAD.