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Purpose

The aim of "iSCAD," the International Spontaneous Coronary Artery Dissection (SCAD) Registry, is to serve as an internationally collaborative, multicenter registry coordinated by an experienced and centralized coordinating center in an effort to increase the pace of participant recruitment, and thereby increase statistical power of studies related to SCAD. The ultimate goal of iSCAD Registry is to facilitate the development of best practices and clinical guidelines for preventing SCAD or its recurrence. This observational study will be prospective and retrospective in its recruitment and will collect clinical information to better understand the natural history and prognosis for SCAD.

Condition

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

Participants with a new diagnosis of SCAD or a history of confirmed or suspected SCAD will be prospectively recruited from either: 1. Inpatient wards of the enrolling medical centers during the acute presentation of SCAD, or 2. Outpatient cardiovascular clinics of enrolling medical centers. Participants must be: - 18 years of age or older - Diagnosis of SCAD or history of SCAD based on coronary angiography, either catheter-based or coronary CTA - Suspected SCAD by coronary angiography

Exclusion Criteria

  1. Coronary dissection in association with atherosclerosis or as a result of iatrogenic injury 2. Inability to provide informed consent 3. Inability to complete study-related patient questionnaires 4. Inability to understand and complete patient questionnaires independently

Study Design

Phase
Study Type
Observational [Patient Registry]
Observational Model
Cohort
Time Perspective
Other

Recruiting Locations

UCLA (University of California, Los Angeles)
Los Angeles, California 93003
Contact:
Tim Canan, MD
805-642-6252
tcanan@mednet.ucla.edu

Columbia University Medical Center
New York, New York 10032
Contact:
Sonia Tolani, MD
st2367@cumc.columbia.edu

Intermountain
Murray, Utah 84107
Contact:
James Orford, MD
801-507-4701
james.orford@imail.org

UT Southwestern
Dallas, Texas 75390
Contact:
Dharam Kumbhani, MD
214-645-8300
dharam.kumbhani@utsouthwestern.edu

Vanderbilt University Medical Center
Nashville, Tennessee 37232
Contact:
Kathryn Lindley, MD
615-322-3218

University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania 15213
Contact:
Agnes Koczo, MD
koczoa@upmc.edu

University of Pennsylvania
Philadelphia, Pennsylvania 19104
Contact:
Jennifer Lewey, MD
800-789-7366
jennifer.lewey@pennmedicine.upenn.edu

Providence
Portland, Oregon 97225
Contact:
Lori Tam, MD
503-216-2229
lori.tam@providence.org

Oklahoma Heart
Oklahoma City, Oklahoma 73120
Contact:
Andrea Richardson
arichardson@okheart.com

University Hospitals--Case Western
Cleveland, Ohio 44106
Contact:
Heather Gornik, MD
216-250-9714
heather.gornik@UHHospitals.org

Atrium Health Sanger Heart and Vascular Institute
Charlotte, North Carolina 28204
Contact:
Esther SH Kim, MD, MPH
704-373-0212
Soo.Kim@atriumhealth.org

Mount Sinai
New York, New York 10029-6574
Contact:
Daniella Kadian-Dodov, MD
daniella.kadian-dodov@mountsinai.org

Kaiser Permanente Northern California
San Francisco, California 94115
Contact:
Sahar Naderi, MD
415-833-2616
sahar.naderi@kp.org

Catholic Medical Center
Manchester, New Hampshire 03102
Contact:
Jaime Makooi
jaime.makooi@cmc-nh.org

Dartmouth-Hitchcock
Lebanon, New Hampshire 03756
Contact:
Stan Henkin, MD
603-650-5724
stanislav.henkin@hitchcock.org

St. Luke's Mid America
Kansas City, Missouri 64111
Contact:
Anna Grodzinsky, MD
816-931-1883
agrodzinsky@saint-lukes.org

Massachusetts General Hospital
Boston, Massachusetts 02114-2696
Contact:
Malissa Wood, MD
617-726-0995
MJWOOD@mgh.harvard.edu

Johns Hopkins
Baltimore, Maryland 21224
Contact:
Jeff Trost, MD
443-997-0270
jtrost2@jhmi.edu

Emory Healthcare System
Atlanta, Georgia 30308
Contact:
Sydney Derrick
sydney.derrick@emory.edu

University of South Florida
Tampa, Florida 33602
Contact:
Daniela Crousillat, MD
crousillatd@usf.edu

Hartford Hospital
Hartford, Connecticut 06106
Contact:
Stephanie Saucier, MD
Stephanie.Saucier@hhchealth.org

University of Colorado
Aurora, Colorado 80045
Contact:
Connie Hess, MD
connie.hess@ucdenver.edu

University of Virginia
Charlottesville, Virginia 22908
Contact:
Angela Taylor, MD
434-243-1000
AMT6B@hscmail.mcc.virginia.edu

More Details

NCT ID
NCT04496687
Status
Recruiting
Sponsor
SCAD Alliance

Study Contact

Esther Kim, MD, MPH
704-373-0212
Soo.Kim@atriumhealth.org

Detailed Description

Spontaneous Coronary Artery Dissection (SCAD) is an under-diagnosed cause of acute coronary syndrome (ACS), myocardial infarction (MI) and sudden cardiac arrest. The inner lining of the coronary artery splits and allows blood to seep into the adjacent layer, forming a blockage (hematoma), or the artery continues to tear, creating a flap of tissue that blocks blood flow in the artery. SCAD strikes generally healthy, younger individuals (average age 42) who do not have traditional cardiac risk factors. Warning signs of SCAD encompass the full range of ACS and MI symptoms, from vague to classic. The cause of SCAD is currently unknown and the psychosocial impact of SCAD is traumatizing. The work of the iSCAD Registry will encompass the physical and psychosocial study of SCAD.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.