Neurobehavioral Mechanisms of Choice in Opioid Use Disorder
The objective of this protocol is to use probabilistic reinforcement learning choice tasks and magnetic resonance neuroimaging to demonstrate the impact of problematic opioid use and opioid withdrawal on dynamic decision-making and reveal the neurobehavioral and neurobiological processes underlying abnormal task performance.
- Opioid Use Disorder
- Eligible Ages
- Between 18 Years and 50 Years
- Eligible Genders
- Accepts Healthy Volunteers
- Must meet moderate/severe criteria for moderate/severe opioid use disorder, report recent prescription or illicit opioid use, and be opioid dependent, as evidenced by either a urine sample positive for recent opioid use or being in frank withdrawal during screening.
- Female subjects must be using an effective form of birth control (e.g., birth control pills, surgical sterilization, IUD, cervical cap with a spermicide, or abstinence).
- Able to speak and read English
- History of, or current, clinically significant physical disease (e.g., respiratory disease [asthma, COPD, sleep apnea], impaired cardiovascular functioning, seizure disorder or CNS tumors) or current or past history of psychiatric disorder that would limit compliance in the studies, other than substance use disorder.
- Meet diagnostic criteria for psychoactive substance use disorder for substances other than opioids (OUD subjects only) or nicotine that would require detoxification (i.e., alcohol, benzodiazepines or barbiturates).
- Contraindications for MRI scanning (e.g., pacemaker, metal implants, claustrophobia, or any other implanted medical device).
- Vision or hearing problems that would preclude completion of experimental tasks.
- At risk for respiratory complications and have predictors of difficult bag mask ventilation (e.g., dentures, very full beard), in case emergency respiratory intervention is needed.
- Seeking treatment for SUD.
- Early Phase 1
- Study Type
- Intervention Model
- Crossover Assignment
- Intervention Model Description
- Within-subjects design
- Primary Purpose
- Basic Science
- Double (Participant, Outcomes Assessor)
- Masking Description
Active treatment followed by placebo treatment
|Participants complete a gambling task during oxycodone administration and then complete the same gambling task during placebo administration.||
Placebo treatment followed by active treatment
|Participants complete a gambling task during placebo administration and then complete the same gambling task during oxycodone administration.||
UK Center for Clinical and Translational Science and nearby locations
- NCT ID
- Joshua A. Lile, Ph.D.
Study ContactJOSHUA LILE, Ph.D.