Automated Imaging Differentiation of Parkinsonism

Purpose

The purpose of this study is to test the performance of the AID-P across 21 sites in the Parkinson Study Group. Each site will perform imaging, clinical scales, diagnosis, and will upload the data to the web-based software tool. The clinical diagnosis will be blinded to the diagnostic algorithm and the imaging diagnosis will be compared to the movement disorders trained neurologist diagnosis.

Conditions

  • Parkinson Disease
  • Multiple System Atrophy, Parkinson Variant
  • Progressive Supranuclear Palsy

Eligibility

Eligible Ages
Between 40 Years and 80 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Parkinson's disease diagnosis within 5-9 years of baseline date - MSAp diagnosis - PSP diagnosis

Exclusion Criteria

  • metal implants in the body that preclude an MRI (pacemaker, metallic clip, neurostimulator, etc) - claustrophobia - pregnancy

Study Design

Phase
Study Type
Observational
Observational Model
Case-Control
Time Perspective
Prospective

Arm Groups

ArmDescriptionAssigned Intervention
Parkinson's disease Clinically diagnosed Parkinson's disease
  • Diagnostic Test: AIDP
    Machine learning algorithm of imaging data
Multiple System Atrophy, Parkinsonian variant Clinically diagnosed Multiple System Atrophy, Parkinsonian variant
  • Diagnostic Test: AIDP
    Machine learning algorithm of imaging data
Progressive Supranuclear Palsy Clinically diagnosed Progressive Supranuclear Palsy
  • Diagnostic Test: AIDP
    Machine learning algorithm of imaging data

Recruiting Locations

UK Center for Clinical and Translational Science and nearby locations

University of Kentucky
Lexington, Kentucky 40536
Contact:
Renee Wagner, RN
859-323-0028
renee.wagner@uky.edu

More Details

NCT ID
NCT05913687
Status
Recruiting
Sponsor
University of Florida

Study Contact

David Vaillancourt, PhD
352-294-1770
vcourt@ufl.edu