UK Center for Clinical and Translational Science

Conditions

• Stress Disorders, Post-Traumatic
• Shame
• Guilt
• Sexual Assault and Rape

Eligibility

Eligible Ages

Over 18 Years

Eligible Genders

All

Accepts Healthy Volunteers

No

Study Contact

Detailed Description

In this multiple baseline single case experimental design with phase shift, up to 100 participants will be screened to identify 12 eligible individuals to participate in all study procedures. After the baseline assessment, participants will be randomized (1:1 ratio) to either a two or four-week baseline phase (assessment-only). Participants will then be randomized (1:1 ratio) to either a 12-session CPT intervention or a 6-session self-compassion intervention. All participants will complete one orientation session at the beginning of the first treatment phase. Following a second three-week baseline phase, all participants will then shift into the alternate intervention. Participants will be invited to complete a post-treatment and one-month follow-up assessment. In total, participants who take part in this research study will be in this research study for up to 34 weeks and will attend up to 20 in-person study visits. Individuals interested in participating in this study will complete a phone screening to determine if they are likely to be eligible and can be scheduled for an in-person diagnostic intake to take place at the Stress Trauma and Recovery Research Collaborative (STARRC) within the UK Clinic for Emotional Health (i.e., the PI's research lab space located on Waller Avenue in an office park rented by the University of Kentucky) or via HIPAA compliant Zoom. All participants will be provided with details regarding the phone screen questions and will be required to provide implied consent over the phone before proceeding with the phone screen. During the intake session, the participant will first be given a written and verbal description of the study and informed consent. The consent form will be presented to the participant on a tablet, or remotely, through REDCap in which they will be asked to provide a digital signature. They may request a paper copy if preferred. If consent is provided, they will be given the option to be emailed a copy. The PI or designated staff will discuss the informed consent form with the participant volunteer. The consent process will take place in a quiet and private room or online via HIPAA compliant Zoom. Participants may take as much time as needed to make a decision about their trial participation and may take the document home if desired. The person obtaining consent will thoroughly explain each element of the document and outline the risks and benefits, alternative treatment(s), and follow-up requirements of the study. Participants will be informed that they can withdraw from the research at any time. Procedures and consent forms will comply with the requirements of the UK Institutional Review Board and Office of Research Integrity's Best Practices for Remote Informed Consent. The experimenter will then complete a consent post-test with participants. If a participant screens out of the study due to a consent capacity issue, any data from that participant that may have been previously collected during the phone screening and/or online surveys will not be used. Participant privacy will be maintained and questions regarding participation will be answered. No coercion or undue influence will be used in the consent process. No research-related procedures will be performed prior to obtaining informed consent. All signatures and dates will be obtained. A copy of the signed consent will be given to the participant. Signed electronic consents will be maintained and stored through REDCap and will be separated from participant data. We do not have reason to expect that participants are likely to have impaired consent capacity in this study. However, in a previous study our lab conducted where we did have this expectation we included a consent capacity evaluation document and found that we liked using it as an extra check that participants were aware of the study details and what they were agreeing to, and could state back to us in their own words what they could do if they became uncomfortable or decided they wished to take a break, skip sections, or discontinue the study. It is now our lab's standard operating procedure to include this measure in all in-person studies. Any study personnel member who obtains informed consent from a patient will not serve as that participant's assigned therapist. Upon referral to the study via the recruitment methods described above, participants will complete a brief telephone screening. The screen will predominantly be conducted by trained undergraduate/post-baccalaureate research/clinic assistants, however the PI, Co-Is, or a supervised graduate students/post-doctoral scholars may also conduct the phone screens. Screening forms for individuals who are deemed to be ineligible for the study will be shredded. Likely eligible participants, determined by the phone screen, will be invited to attend the intake in-person in the PI's research lab at the Clinic for Emotional Health or via HIPAA-compliant video conferencing service (i.e., Zoom via the UK HealthCare portal). As described above (see "Informed Consent" section), a study assessor (i.e., doctoral students in clinical psychology/post-doctoral scholar/PI/Co-Is) will review study procedures with potential participants and ask them to provide their informed consent. After informed consent is provided, an interview-based diagnostic assessment will be administered in order to confirm clinical inclusion/exclusion criteria. This assessment visit will be video or audio-recorded provided participants give their consent for this. Next, participants will be asked to complete a battery of self-report questionnaires, which will assess symptoms of anxiety/depression, level of functioning (e.g., quality of life), experiential avoidance, self-compassion, and perceptions of how their history of sexual trauma have impacted their life. Those who are deemed ineligible after this assessment will be withdrawn. Eligible participants will then be randomized to either a two- or four-week baseline where they will complete weekly measures of PTSD symptoms mental contamination, trauma-related shame and guilt, and symptoms of anxiety/depression. This battery will be repeated each week during therapy sessions, along with additional post-session ratings about treatment credibility and therapeutic alliance. Participants will then be randomly assigned to one of two treatment orders (CPT, SC or SC, CPT) and will be scheduled for their next study session either in-person or via HIPAA compliant Zoom. All participants will first be scheduled for a therapy orientation session prior to beginning either CPT or SC. The therapy orientation session will be used to develop rapport between the therapist and participant, and will involve an interview to assess for details of the index traumatic event and experiences of trauma-related mental contamination. Following completion of each treatment (12 or 6 sessions), participants will be asked to provide satisfaction ratings and written qualitative feedback on their experience with the treatment they received. Participants will then enter a second three-week return to assessment period where they will continue to complete questionnaires weekly before beginning the second treatment module. Participants will also complete a post-treatment questionnaire packet and continue to track their symptoms weekly for three weeks following the conclusion of treatment via self-report. All therapy sessions will last for approximately 60-90 minutes in duration. It is important to note that the therapeutic strategies involved in both treatments are all common, evidence-based cognitive-behavioral- or mindfulness-based strategies. The treatments involve reading from an established manual (Cognitive Processing Therapy for PTSD or Compassion-Based Therapy for Trauma-Related Shame and Posttraumatic Stress) and completing homework assignments outside of the treatment session. These treatment sessions will be audio- or video-recorded provided participants give their consent for this; this will allow study staff to rate sessions for fidelity to the protocol and will be used for clinical supervision. All self-report questionnaires will be completed online via REDCap. This survey platform is designed specifically for collection of research data, and therefore meets the privacy standards imposed on health care records by the Health Insurance Portability and Accountability Act (HIPAA). Questionnaires will be completed on-site using a study iPad or participants will be sent a link via email to complete the survey batteries during their own time. Finally, although we anticipate that most patients will prefer to complete these measure electronically, we can provide paper and pencil versions of the questionnaires if requested. Data collection will be accomplished via phone screening questions, diagnostic interview, and self-report questionnaires attached below. Through these measures we will collect data regarding participants' experiences with psychological symptoms, life functioning, and treatment satisfaction. The measures will be administered according to the following schedule: Intake and Final Treatment Sessions: Diagnostic Interview for Anxiety, Mood, and Obsessive-Compulsive and Related Neuropsychiatric Disorders (DIAMOND) interview (Only at Intake) Columbia-Suicide Severity Rating Scale (CSSRS) with SAFE-T Risk Assessment Demographics (Only at Intake) PTSD Checklist for DSM-5 (PCL-5) - Weekly Posttraumatic Experience of Mental Contamination (PEMC) - Weekly Trauma-Related Symptom Inventory (TRSI) - Weekly Trauma-Related Guilt Inventory (TRGI) - Weekly Overall Depression Severity and Impairment Scale (ODSIS) - Weekly Overall Anxiety Severity and Impairment Scale (OASIS) - Weekly Centrality of Events Scale (CES) Self-Compassion Scale (SCS) Obsessive Compulsive Inventory-Revised (OCI-R) Brief Experiential Avoidance Questionnaire (BEAQ) Quality of Life Enjoyment and Satisfaction Questionnaire-Short Form (Q-LES-Q) Patient Satisfaction Form (final treatment sessions only) Treatment Orientation Session: Treatment Services Tracking Form (Intake only) Trauma Interview Pre-Session (Weekly): PCL-5 - Weekly PEMC - Weekly TRSI - Weekly TRGI - Weekly CSSRS - Weekly (in-person sessions only) Treatment Services Tracking Form - Weekly (in-person sessions only) Post-Session (Weekly): ODSIS - Weekly OASIS - Weekly Helping Alliance Questionnaire-II (HAQ-II) - Patient and Therapist CEQ (post-1st treatment sessions only) The goal of Aim 1 is to collect descriptive information regarding prevalence of trauma history and PTSD, perceptions of connections between trauma history and substance use, and interest in trauma-informed treatment. This information will be utilized to a) support the feasibility of a future grant application and b) identify potential patients for the treatment portion of the study. Though the primary focus of Aim 2 is to collect data regarding feasibility, acceptability, and patient feedback regarding areas of modification to inform a future grant proposal, we plan to utilize a randomized, nonconcurrent multiple baseline design across participants (Barlow et al., 2009; Kazdin, 2011). This is a form of single-case experimental design that provides a time and cost-effective method of evaluating initial efficacy or effectiveness of an intervention while controlling for the passage of time and repeated assessment in small numbers of patients. Patients will be randomized to either a 2- (n=3) or 4-week (n =3) baseline assessment phase where weekly self-report measures will be completed prior to initiating each treatment. Randomizing to varying baseline periods enables assessments of whether symptoms change (only or more rapidly) when the intervention is applied (i.e., each participant acts as their own control). Participants will also be randomly assigned to the order that they receive the treatment, with a 3-week return to baseline between treatments to allow us to examine how symptoms change within each intervention period. This design allows for causal inferences and controls for many threats to internal validity. Consistent with established guidelines, quantitative data analysis will primarily be conducted via visual inspection of graphed data within- and between-subjects to evaluate the magnitude and rate of change across the baseline and treatment phases (Barlow et al., 2009; Kazdin, 2011). This will be supplemented by examining within-person mean difference effect sizes for each outcome using a d-statistic developed for single case designs and calculating the percentage of patients who evidence reliable change on symptom measures (Jacobson & Truax, 1991; Shadish et al., 2014).