Opioid and Cannabinoid Interactions
Purpose
This study will examine the effects of doses of marijuana/placebo and doses of opioid/placebo, alone and in combination. The primary outcomes are related to pharmacodynamic measures (subjective ratings of drug liking and other abuse-related effects; physiological outcomes) to determine the interaction effects of these compounds.
Conditions
- Marijuana Usage
- Opioid Use
Eligibility
- Eligible Ages
- Between 18 Years and 50 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Healthy adults ages 18-50 - Current non-medical use of opioids and marijuana
Exclusion Criteria
- Physical dependence on opioids, alcohol benzodiazepines/sedative/hypnotics - Seeking treatment for drug use - Significant medical problems
Study Design
- Phase
- Phase 1
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Sequential Assignment
- Primary Purpose
- Basic Science
- Masking
- Double (Participant, Investigator)
- Masking Description
- This is a randomized, double-blind, double-dummy, placebo-controlled design
Arm Groups
Arm | Description | Assigned Intervention |
---|---|---|
Experimental Vaporized Marijuana |
Participants will receive non-therapeutic, experimental doses of active or placebo. vaporized marijuana. Active marijuana/placebo will be administered once per session and will be administered via a vaporizer. |
|
Experimental Opioid Agonist |
Participants will receive non-therapeutic, experimental doses of an active opioid agonist or placebo. Active opioid agonist/placebo will be administered once per session and will be administered intranasally (snorting). |
|
Experimental Opioid Agonist/Marijuana Combination |
Participants will receive non-therapeutic, experimental doses of active opioid/placebo in combination with non-therapeutic, experimental doses of active vaporized marijuana/placebo. Opioid/placebo and marijuana/placebo doses will be administered once during each session. It is possible to receive both active drugs on the same day. Opioid doses will be administered intranasally; marijuana doses will be administered via vaporizer. |
|
Recruiting Locations
More Details
- NCT ID
- NCT03705559
- Status
- Completed
- Sponsor
- Shanna Babalonis, PhD