Opioid and Cannabinoid Interactions

Purpose

This study will examine the effects of doses of marijuana/placebo and doses of opioid/placebo, alone and in combination. The primary outcomes are related to pharmacodynamic measures (subjective ratings of drug liking and other abuse-related effects; physiological outcomes) to determine the interaction effects of these compounds.

Conditions

  • Marijuana Usage
  • Opioid Use

Eligibility

Eligible Ages
Between 18 Years and 50 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Healthy adults ages 18-50 - Current non-medical use of opioids and marijuana

Exclusion Criteria

  • Physical dependence on opioids, alcohol benzodiazepines/sedative/hypnotics - Seeking treatment for drug use - Significant medical problems

Study Design

Phase
Phase 1
Study Type
Interventional
Allocation
Randomized
Intervention Model
Sequential Assignment
Primary Purpose
Basic Science
Masking
Double (Participant, Investigator)
Masking Description
This is a randomized, double-blind, double-dummy, placebo-controlled design

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Vaporized Marijuana
Participants will receive non-therapeutic, experimental doses of active or placebo. vaporized marijuana. Active marijuana/placebo will be administered once per session and will be administered via a vaporizer.
  • Drug: Vaporized Marijuana
    Active Marijuana or Placebo, administered through vaporizer
    Other names:
    • Cannabis
Experimental
Opioid Agonist
Participants will receive non-therapeutic, experimental doses of an active opioid agonist or placebo. Active opioid agonist/placebo will be administered once per session and will be administered intranasally (snorting).
  • Drug: Opioid Agonist
    Active Opioid Agonist or Placebo, administered intranasally
Experimental
Opioid Agonist/Marijuana Combination
Participants will receive non-therapeutic, experimental doses of active opioid/placebo in combination with non-therapeutic, experimental doses of active vaporized marijuana/placebo. Opioid/placebo and marijuana/placebo doses will be administered once during each session. It is possible to receive both active drugs on the same day. Opioid doses will be administered intranasally; marijuana doses will be administered via vaporizer.
  • Drug: Vaporized Marijuana
    Active Marijuana or Placebo, administered through vaporizer
    Other names:
    • Cannabis
  • Drug: Opioid Agonist
    Active Opioid Agonist or Placebo, administered intranasally

Recruiting Locations

More Details

NCT ID
NCT03705559
Status
Completed
Sponsor
Shanna Babalonis, PhD