Search Clinical Trials
Sponsor Condition of Interest |
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NM Balance Regulation With ULLS and Loss of Sleep
Lance Bollinger
Muscle Weakness
Quadriceps Muscle Atrophy
Sleep Disturbance
The goal of this trial is to learn about how restricted sleep and not bearing weight on
the leg affects muscle strength and posture control. Participants will walk exclusively
on one leg, sleep at differing intervals, and complete posture tests, muscle strength
tests, and muscle imaging. Researchers... expand
The goal of this trial is to learn about how restricted sleep and not bearing weight on the leg affects muscle strength and posture control. Participants will walk exclusively on one leg, sleep at differing intervals, and complete posture tests, muscle strength tests, and muscle imaging. Researchers will compare adequate sleep and restricted sleep to see if muscle strength and posture are affected. Type: Interventional Start Date: Aug 2023 |
Multilevel HPV Self-Testing Intervention for the Increase of Cervical Cancer Screening Among Women in...
Ohio State University Comprehensive Cancer Center
Cervical Carcinoma
Human Papillomavirus Infection
This trial studies how well a multilevel human papillomavirus (HPV) self-testing
intervention works in increasing cervical cancer screening among women in Appalachia.
Most cases of cervical cancer occur among unscreened and underscreened women. A
multilevel HPV self-testing intervention may help to... expand
This trial studies how well a multilevel human papillomavirus (HPV) self-testing intervention works in increasing cervical cancer screening among women in Appalachia. Most cases of cervical cancer occur among unscreened and underscreened women. A multilevel HPV self-testing intervention may help to improve cervical cancer screening rates. Type: Interventional Start Date: Aug 2021 |
Biomarker and Edema Attenuation in IntraCerebral Hemorrhage (BEACH)
Johns Hopkins University
Intracerebral Hemorrhage
This first-in-patient phase 2a pilot study will assess the safety and tolerability of
MW01-6-189WH (hereafter called MW189) in patients with Intracerebral Hemorrhage (ICH). expand
This first-in-patient phase 2a pilot study will assess the safety and tolerability of MW01-6-189WH (hereafter called MW189) in patients with Intracerebral Hemorrhage (ICH). Type: Interventional Start Date: Oct 2022 |
Mechanisms for Activation of Beige Adipose Tissue in Humans
Philip Kern
PreDiabetes
Mirabegron (Myrbetriq®, Astellas) is a highly specific and well-tolerated ß3 agonist
marketed for overactive bladder. This trial will assess the effects of mirabegron on
glucose tolerance and adipose tissue in prediabetic patients expand
Mirabegron (Myrbetriq®, Astellas) is a highly specific and well-tolerated ß3 agonist marketed for overactive bladder. This trial will assess the effects of mirabegron on glucose tolerance and adipose tissue in prediabetic patients Type: Interventional Start Date: Dec 2020 |
Evaluating Genomic Testing in Human Cancer & Outcomes of Targeted Therapies
Rachel Miller
Cancer
This is a substudy (Part 2) of a larger two-part clinical trial including both
observational and therapeutic (interventional) cohorts to assess the progression free
survival ratio of patients treated with a targeted therapy based on genomic analysis
results and recommendation by the Markey Cancer... expand
This is a substudy (Part 2) of a larger two-part clinical trial including both observational and therapeutic (interventional) cohorts to assess the progression free survival ratio of patients treated with a targeted therapy based on genomic analysis results and recommendation by the Markey Cancer Center Molecular Tumor Board (MCC MTB). Type: Interventional Start Date: Apr 2017 |
Lumbar Fusion With Porous Versus Non-Porous Cages
University of Kentucky
Spinal Fusion
Lumbar Fusion
Arthrodesis
Spondylolisthesis
Pseudarthrosis
The objective of this single site, randomized controlled trial is to assess and compare
radiographic and clinical outcomes in patients who are to undergo lumbar interbody fusion
procedures (TLIF), supplemented with pedicle screw instrumentation, using one of the
following interventions:
1. Porous... expand
The objective of this single site, randomized controlled trial is to assess and compare radiographic and clinical outcomes in patients who are to undergo lumbar interbody fusion procedures (TLIF), supplemented with pedicle screw instrumentation, using one of the following interventions: 1. Porous titanium cages 2. Non-porous titanium-coated poly-ether-ether-ketone (PEEK) cages. Type: Interventional Start Date: Nov 2022 |
I Vaccinate: Testing Multi-Level Interventions to Improve HPV Vaccination
Ohio State University Comprehensive Cancer Center
Cervical Carcinoma
Human Papillomavirus-Related Malignant Neoplasm
This trial studies how well a multi-level health system-based intervention works in
improving human papillomavirus (HPV) vaccine initiation and completion among children in
health systems in four Appalachian states. Utilizing educational and promotional
materials and electronic health record reminders,... expand
This trial studies how well a multi-level health system-based intervention works in improving human papillomavirus (HPV) vaccine initiation and completion among children in health systems in four Appalachian states. Utilizing educational and promotional materials and electronic health record reminders, may improve the uptake of the HPV vaccine in children and young adults, ultimately preventing the development of cervical cancer. Type: Interventional Start Date: Oct 2020 |
Citadel Embolization Device Study
Stryker Neurovascular
Unruptured Wide-neck Aneurysms
The purpose of this study is to gather safety and effectiveness data on Stryker
Neurovascular's Next Generation Target Detachable Coil (hereafter referred to as the
Citadel Embolization Device), when used with Target Detachable Coils, in the treatment of
wide-neck intracranial aneurysms. expand
The purpose of this study is to gather safety and effectiveness data on Stryker Neurovascular's Next Generation Target Detachable Coil (hereafter referred to as the Citadel Embolization Device), when used with Target Detachable Coils, in the treatment of wide-neck intracranial aneurysms. Type: Interventional Start Date: Jul 2019 |
Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection
University of Calgary
Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection
Hemolytic-Uremic Syndrome
The objective of this study is to determine if early high volume intravenous fluid
administration (hyperhydration) may be effective in mitigating or preventing
complications of shiga toxin-producing E. coli (STEC) infection in children and
adolescents when compared with traditional approaches (conservative... expand
The objective of this study is to determine if early high volume intravenous fluid administration (hyperhydration) may be effective in mitigating or preventing complications of shiga toxin-producing E. coli (STEC) infection in children and adolescents when compared with traditional approaches (conservative fluid management). Type: Interventional Start Date: Sep 2022 |
A Trial to Learn How Well Linvoseltamab Works Compared to the Combination of Elotuzumab, Pomalidomide...
Regeneron Pharmaceuticals
Relapsed Refractory Multiple Myeloma (RRMM)
This study is researching an experimental drug called linvoseltamab, also called
REGN5458.
Linvoseltamab has previously been studied by itself (without other cancer drugs) in
participants who had advanced multiple myeloma that returned and needed to be treated
again after many other therapies had... expand
This study is researching an experimental drug called linvoseltamab, also called REGN5458. Linvoseltamab has previously been studied by itself (without other cancer drugs) in participants who had advanced multiple myeloma that returned and needed to be treated again after many other therapies had failed. These participants were no longer benefiting from standard medications and had no good treatment options. In that study, some participants who were treated with linvoseltamab had improvement of their myeloma (shrinkage of their tumors), including some participants who had complete responses (that is, the treatment got rid of all evidence of myeloma in their bodies). This study is focused on participants who have multiple myeloma that has returned or needs to be treated again after one to four prior treatments and have standard cancer treatment options available to them. The aim of this study is to see how safe and effective linvoseltamab is compared to a combination of three cancer drugs: elotuzumab, pomalidomide and dexamethasone, (called EPd) in participants who have returned after having received prior treatment that included lenalidomide, a proteosome inhibitor, and (for participants in some countries) a cluster of differentiation 38 (CD38) antibody. Half of the participants in this study will get linvoseltamab, and the other half will get EPd. This study is looking at several other research questions, including: - How long participants benefit from receiving linvoseltamab compared with EPd - How many participants treated with linvoseltamab or EPd have improvement of their multiple myeloma and by how much - What side effects happen from taking linvoseltamab compared to EPd - How long participants live while receiving treatment or after treatment with linvoseltamab compared to EPd - If there is any improvement in pain after treatment with linvoseltamab compared to EPd Type: Interventional Start Date: Sep 2023 |
Life's End Benefits of cannaBidiol and tetrahYdrocannabinol
University of Southern California
Agitation
Dementia
This is a multicenter randomized double-blind placebo-controlled Phase 2 study of an oral
combination of tetrahydrocannabinol (THC) and cannabidiol (CBD) compared to placebo over
12 weeks. This study is designed to test the hypothesis that treatment with an oral
combination of THC/CBD will reduce... expand
This is a multicenter randomized double-blind placebo-controlled Phase 2 study of an oral combination of tetrahydrocannabinol (THC) and cannabidiol (CBD) compared to placebo over 12 weeks. This study is designed to test the hypothesis that treatment with an oral combination of THC/CBD will reduce agitation hospice care-eligible patients with agitation and dementia as measured by the Cohen Mansfield Agitation Inventory (CMAI) when compared to placebo at 2 weeks. This study will enroll approximately 150 participants of any gender at least 40 years of age who are hospice care-eligible with agitation and dementia (HAD). Participants will be randomized (50:50) to either active study drug (T2:C100) or placebo. The double-blind period of this study is 12 weeks. A 12 week optional open-label extension will be offered to participants who complete the double-blind period. Type: Interventional Start Date: Dec 2023 |
GEN1042 Safety Trial and Anti-tumor Activity in Participants With Malignant Solid Tumors
Genmab
Malignant Solid Tumor
Non-Small Cell Lung Cancer (NSCLC)
Colorectal Cancer (CRC)
Melanoma
Head and Neck Squamous Cell Carcinoma (HNSCC)
The goal of this trial is to learn about the antibody GEN1042 when it is used alone and
when it is used together with another antibody cancer drug, pembrolizumab (with or
without chemotherapy), for treatment of participants with certain types of cancer. expand
The goal of this trial is to learn about the antibody GEN1042 when it is used alone and when it is used together with another antibody cancer drug, pembrolizumab (with or without chemotherapy), for treatment of participants with certain types of cancer. Type: Interventional Start Date: Sep 2019 |
Continuous vs. Intermittent Infusion Vancomycin
Aaron Cook
Vancomycin
Hospitalized adult participants prescribed vancomycin by their treating physician will be
randomized to receive vancomycin via continuous or intermittent infusion and measures of
kidney function and injury will be collected. expand
Hospitalized adult participants prescribed vancomycin by their treating physician will be randomized to receive vancomycin via continuous or intermittent infusion and measures of kidney function and injury will be collected. Type: Interventional Start Date: May 2023 |
Cannabis and Opioid Use Disorder
University of Kentucky
Opioid Use Disorder
This study plans to enroll participants with opioid use disorder who are not currently
seeking treatment to assess the effects of cannabis on opioid withdrawal and other
related outcomes. expand
This study plans to enroll participants with opioid use disorder who are not currently seeking treatment to assess the effects of cannabis on opioid withdrawal and other related outcomes. Type: Interventional Start Date: Sep 2024 |
Integrated Outpatient Treatment of Opioid Use Disorder and Severe Injection Related Infections
Laura Fanucchi
Drug Use
Opioid-use Disorder
This study will assess the efficacy of an integrated outpatient treatment model for
persons with opioid use disorder and injection related infections. The investigators
hypothesize that outpatient antibiotic treatment coupled with comprehensive treatment for
opioid use disorder will demonstrate a... expand
This study will assess the efficacy of an integrated outpatient treatment model for persons with opioid use disorder and injection related infections. The investigators hypothesize that outpatient antibiotic treatment coupled with comprehensive treatment for opioid use disorder will demonstrate a safe and effective way to manage patients. Results could improve the current protocols for the treatment of individuals with opioid use disorder and severe infections. Type: Interventional Start Date: Mar 2021 |
Exercise and Emotional Learning in Posttraumatic Stress Disorder
Christal L Badour
PTSD
The goal of this clinical trial is to test how exercise affects learning and memory
processes relevant to the treatment of PTSD. Participants will complete a baseline intake
followed by two experimental sessions. During the first experimental session,
participants will undergo an MRI session of imaginal... expand
The goal of this clinical trial is to test how exercise affects learning and memory processes relevant to the treatment of PTSD. Participants will complete a baseline intake followed by two experimental sessions. During the first experimental session, participants will undergo an MRI session of imaginal exposure to traumatic memory cues followed by 30-minutes of moderate intensity exercise or low intensity exercise. Participants will complete a second session of imaginal exposure with MRI 24 hours later. Type: Interventional Start Date: May 2024 |
Targeted Alpha-Particle Therapy for Advanced SSTR2 Positive Neuroendocrine Tumors
Perspective Therapeutics
Neuroendocrine Tumors
Neuroendocrine Tumor of the Lung
Neuroendocrine Tumor of Pancreas
Neuroendocrine Carcinoma Metastatic
Neuroendocrine Tumor Carcinoid
This study is Phase I/IIa First-in-Human Study of [212Pb]VMT-α-NET Targeted
Alpha-Particle Therapy for Advanced SSTR2 Positive Neuroendocrine Tumors expand
This study is Phase I/IIa First-in-Human Study of [212Pb]VMT-α-NET Targeted Alpha-Particle Therapy for Advanced SSTR2 Positive Neuroendocrine Tumors Type: Interventional Start Date: Sep 2023 |
A Study With Eptinezumab in Children and Adolescents (6 to 17 Years) With Chronic or Episodic Migraine
H. Lundbeck A/S
Migraine
The main goal of the study is to assess the long-term safety of eptinezumab on children
and adolescents ages 6 to 17 with chronic or episodic migraine. expand
The main goal of the study is to assess the long-term safety of eptinezumab on children and adolescents ages 6 to 17 with chronic or episodic migraine. Type: Interventional Start Date: Dec 2021 |
CHIlled Platelet Study "CHIPS"
Philip Spinella
Acute Blood Loss
A phase 3 randomized partial blind storage duration ranging study in patients undergoing
complex cardiac surgery that will compare the transfusion of cold stored platelets to
standard room temperature stored platelets. The primary objective is to establish that
cold stored platelets have a non-inferiority... expand
A phase 3 randomized partial blind storage duration ranging study in patients undergoing complex cardiac surgery that will compare the transfusion of cold stored platelets to standard room temperature stored platelets. The primary objective is to establish that cold stored platelets have a non-inferiority (or superiority) to room temperature platelets. Type: Interventional Start Date: Oct 2021 |
Pediatric Oncology Nutrition Intervention Trial
Corey Hawes
Pediatric Cancer
Nutrition Related Cancer
Nutrition Aspect of Cancer
Muscle Loss
Malnutrition, Child
Nearly 60% of pediatric patients diagnosed with cancer develop malnutrition caused by a
combination of disease burden, side effects of chemotherapy, and the intensity of cancer
treatment. These patients are known to have an increased risk of infection,
treatment-related toxicity, inferior clinical... expand
Nearly 60% of pediatric patients diagnosed with cancer develop malnutrition caused by a combination of disease burden, side effects of chemotherapy, and the intensity of cancer treatment. These patients are known to have an increased risk of infection, treatment-related toxicity, inferior clinical outcomes, and increased risk of mortality. Malnutrition may progress to cancer cachexia, characterized by anorexia, increased inflammation, decreased fat, and decreased muscle mass with subsequent weight loss, which is associated with decreased overall survival. The goal of the proposed research is to determine changes in body composition, weight status, and nutritional status between common nutrition interventions including oral nutrition supplements (ONS), appetite stimulants, and enteral nutrition (EN) among pediatric cancer patients. A secondary goal of this research is to utilize the findings to develop clinical nutrition guidelines for this patient population. The specific objective of the research proposed is to solve the lack of evidence to adequately treat nutritional deficits in the pediatric oncology population. Without this data, there is a lack of clinical consistency in the initiation and selection of appropriate nutrition interventions to provide a more definitive pathway of care. This study can help formulate a clinical guideline for this patient population before, during, and after treatment. Type: Interventional Start Date: Jan 2024 |
Precision Medicine Randomized Clinical Trial Comparing Molecular Tumor Board Assisted Care to Usual Care
Timothy Mullett
Non-Small Cell Lung Cancer
This trial will compare Molecular Tumor Board (MTB) assisted care to usual care for
patients who have newly diagnosed histologically or cytologically confirmed stage IIb-IV
Non-Small Cell Lung Cancer (NSCLC) and are planning to undergo treatment for their
cancer. expand
This trial will compare Molecular Tumor Board (MTB) assisted care to usual care for patients who have newly diagnosed histologically or cytologically confirmed stage IIb-IV Non-Small Cell Lung Cancer (NSCLC) and are planning to undergo treatment for their cancer. Type: Interventional Start Date: Apr 2022 |
Study of Tirabrutinib (ONO-4059) in Patients With Primary Central Nervous System Lymphoma (PROSPECT Study)
Ono Pharmaceutical Co. Ltd
Refractory Primary Central Nervous System Lymphoma
Primary CNS Lymphoma
This study will evaluate the efficacy, safety, and pharmacokinetics of tirabrutinib
monotherapy in patients with relapsed or refractory PCNSL (Part A), and tirabrutinib in
combination with one of two different high dose methotrexate based regimens
(methotrexate/ temozolomide/rituximab or rituximab/methotrexate/procarbazine/
vincristine)... expand
This study will evaluate the efficacy, safety, and pharmacokinetics of tirabrutinib monotherapy in patients with relapsed or refractory PCNSL (Part A), and tirabrutinib in combination with one of two different high dose methotrexate based regimens (methotrexate/ temozolomide/rituximab or rituximab/methotrexate/procarbazine/ vincristine) as first line therapy in patients with newly diagnosed, treatment naïve PCNSL (Part B) Type: Interventional Start Date: Dec 2021 |
School Screening and Telemedicine Specialty Referral to Address Childhood Hearing Loss in Rural Kentucky
University of Arkansas
Hearing Loss
This trial will evaluate a multilevel intervention (STAR model) that combines mobile
health (mHealth) hearing screening tools with telemedicine technology for specialty care
access in rural Kentucky schools. An initial version of the model was used in rural
Alaska where telemedicine-based specialty... expand
This trial will evaluate a multilevel intervention (STAR model) that combines mobile health (mHealth) hearing screening tools with telemedicine technology for specialty care access in rural Kentucky schools. An initial version of the model was used in rural Alaska where telemedicine-based specialty referral improved both proportion of children receiving follow-up and time to follow-up. The refined STAR model will utilize an enhanced mHealth screening protocol that includes tympanometry for the detection of middle ear disease. The STAR model will also include a specialty telemedicine referral process in schools for children who refer school screening. Type: Interventional Start Date: Sep 2022 |
Reclaiming Your Life After Sexual Trauma
Jesse McCann
Stress Disorders, Post-Traumatic
Sexual Assault and Rape
Mental contamination-an internal experience of dirtiness evoked in the absence of
physical contact with an external source-has been linked to the development and
maintenance of posttraumatic stress disorder (PTSD) following exposure to sexual abuse or
assault (Adams et al., 2014; Badour et al., 2013;... expand
Mental contamination-an internal experience of dirtiness evoked in the absence of physical contact with an external source-has been linked to the development and maintenance of posttraumatic stress disorder (PTSD) following exposure to sexual abuse or assault (Adams et al., 2014; Badour et al., 2013; Brake et al., 2017). Mental contamination has been associated with greater PTSD severity (Rachman et al., 2015) and higher elevations in specific PTSD symptom clusters (particularly those of intrusive re-experiencing, negative cognitions/mood, and arousal/reactivity; Brake et al., 2019; Fergus & Bardeen, 2016). Additionally, trauma-related mental contamination has been linked to a number of negative posttraumatic emotions such as shame, guilt, disgust, and anger (Fairbrother & Rachman, 2004; Radomsky & Elliott, 2009). Despite clear and consistent links between mental contamination and problematic posttraumatic outcomes following sexual trauma, there is a dearth of research investigating how existing or promising new interventions for PTSD impact mental contamination. Written Exposure Therapy (WET) is a five-session treatment for PTSD that was designed to be both brief and easy to administer (Sloan et al., 2012). According to Sloan and colleagues' (2012) protocol, sessions broadly involve 30-minute exposures in which the patient writes about the events of their trauma in detail, followed by 10 minutes of discussing the exposure with the therapist. This treatment protocol has minimal therapist involvement, no homework assignments, and shorter treatment sessions. Research shows that WET is efficacious among different samples (e.g., survivors of motor vehicle accidents and combat veterans), has low dropout rates, treatment satisfaction is high, and the gains seen by participants after completion are maintained at follow-up (Sloan et al., 2012, 2013, 2018; Thompson-Hollands et al., 2018, 2019). Given these factors, WET has the potential to be a useful intervention in reducing symptoms of PTSD among a sample of survivors of sexual trauma. Given its relevance to this trauma population, a test of this intervention for its impact on reducing trauma-related mental contamination is also needed. The current study will use Single Case Experimental Design to isolate and evaluate the effects of WET in reducing both PTSD symptoms and trauma-related mental contamination among individuals with PTSD resulting from sexual trauma. Aims: Explore whether participants demonstrate reductions in mental contamination and PTSD symptoms in response to 5 sessions of WET. Visual inspection analysis and statistical methods will be used to draw conclusions regarding the effects of the interventions on PTSD symptoms and mental contamination. Type: Interventional Start Date: Mar 2022 |
Cervical Cancer Prevention for Black Adults
Adebola Adegboyega
Cervical Cancer
The goal of this study is to develop and pilot test an intervention, entitled Health is
Wealth: A Cervical Health Program, designed to promote screening and reduce perceived
barriers to Cervical Cancer (CC) screening.
Aim 1: Examine general awareness and cultural factors (fatalism,
religiosity/spirituality,... expand
The goal of this study is to develop and pilot test an intervention, entitled Health is Wealth: A Cervical Health Program, designed to promote screening and reduce perceived barriers to Cervical Cancer (CC) screening. Aim 1: Examine general awareness and cultural factors (fatalism, religiosity/spirituality, temporal orientation, medical mistrust, and acculturation) related to cancer control and prevention among African Americans (AA) and Sub Saharan African (SAI) Immigrants. Aim 2: Examine the socioecological barriers and facilitators to CC screening and self-sampling to inform tailoring of an evidenced based cervical health program to promote CC screening. Aim 3: Assess feasibility, acceptability, and preliminary efficacy in a pilot test of the Health is Wealth: A Cervical Health Program among 30 AA and 30 SAI women using quasi-experimental design. This study will take place in 2 phases. Type: Interventional Start Date: Jan 2023 |
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