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MOON Shoulder Instability-Cohort of Patients Undergoing Operative Treatment.
Carolyn M Hettrich
Other Instability, Shoulder
Dislocations
Subluxations
Recurrent Dislocation of Shoulder Region
This project will be a multi-center, prospective longitudinal cohort for all patients
undergoing primary shoulder instability surgery, excluding isolated SLAP repairs. We will be
looking for risk factors for recurrent instability, revision surgery, and poor outcomes.
Patients... expand
This project will be a multi-center, prospective longitudinal cohort for all patients undergoing primary shoulder instability surgery, excluding isolated SLAP repairs. We will be looking for risk factors for recurrent instability, revision surgery, and poor outcomes. Patients will be asked to complete the RAND-36, ASES, Shoulder Activity, EQ-5D and WOSI outcome measures, as well as demographic and socioeconomic information. Surgeons will complete a form after surgery with information on radiographic findings, physical exam, surgical findings, and the repair. Patients will wear a sling post-operatively, and follow standardized rehabilitation protocols, including physical therapy. Patients will be sent outcome questionnaires at 2, 6, 10, and 20 years after surgery. Type: Observational [Patient Registry] Start Date: Aug 2012 |
Allo vs Hypomethylating/Best Supportive Care in MDS (BMT CTN 1102)
Medical College of Wisconsin
MDS
This study is designed as a multicenter trial, with biological assignment to one of two study
arms; Arm 1: Reduced intensity conditioning allogeneic hematopoietic cell transplantation
(RIC-alloHCT), Arm 2: Non-Transplant Therapy/Best Supportive Care.
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This study is designed as a multicenter trial, with biological assignment to one of two study arms; Arm 1: Reduced intensity conditioning allogeneic hematopoietic cell transplantation (RIC-alloHCT), Arm 2: Non-Transplant Therapy/Best Supportive Care. Type: Interventional Start Date: Dec 2013 |
Brief Online Interventions for Alcohol Use
Craig Rush
Alcohol Use Disorder
The purpose of this study is to test the feasibility and acceptability of delivering
cognitive training over mTurk. Subjects will be randomized to a 1) inhibitory control
training condition, 2) working memory training condition, or 3) control training condition.
Recent studies... expand
The purpose of this study is to test the feasibility and acceptability of delivering cognitive training over mTurk. Subjects will be randomized to a 1) inhibitory control training condition, 2) working memory training condition, or 3) control training condition. Recent studies have also demonstrated the feasibility and potential efficacy of delivering brief normative feedback to reduce alcohol consumption through mTurk. In these brief interventions, subjects are provided information about their drinking compared to their same age and gendered peers. Approximately half of the subjects in each cognitive training group will receive normative feedback to evaluate effects on alcohol consumption and possible interactions with cognitive training. This study will focus on alcohol use given the ease and clinical acceptance of alcohol use self-report as a primary outcome. Type: Interventional Start Date: Feb 2018 |
TVB 2640 for Resectable Colon Cancer Other Resectable Cancers; a Window Trial.
Mark Evers
Colon Cancer
Primary Objective
• To evaluate the pharmacodynamic effects on metabolic endpoints (malonyl carnitine and
tripalmitin levels) following short-term treatment with TVB-2640 in patients with resectable
cancers
Secondary Objectives
- To determine if short-term treatment... expand
Primary Objective • To evaluate the pharmacodynamic effects on metabolic endpoints (malonyl carnitine and tripalmitin levels) following short-term treatment with TVB-2640 in patients with resectable cancers Secondary Objectives - To determine if short-term treatment with TVB-2640 decreases cancer cell proliferation. - To examine other biological endpoints and determine if TVB-2640 inhibits cell survival signaling and lipid biogenesis. - To perform comprehensive metabolomic analysis in tumor tissues to identify metabolic alterations induced by TVB-2640 treatment. - To correlate FASN levels in tumor with metabolic and biological endpoints to determine if FASN inhibition has more pronounced effects in patients with increased expression. Type: Interventional Start Date: Jan 2017 |
Implantation of the HiRes90K™ Advantage Cochlear Implant With HiFocus™ Mid-Scala and Development of a...
Advanced Bionics
Hearing Loss
Partial Deafness
Hearing Disorders
Ear Diseases
Otorhinolaryngologic Diseases
The purpose of this feasibility study is to evaluate whether low-frequency acoustic hearing
sensitivity can be preserved in newly implanted adults with partial deafness (considerable
low frequency acoustic hearing profiles with severe-to-profound high frequency sensorineural... expand
The purpose of this feasibility study is to evaluate whether low-frequency acoustic hearing sensitivity can be preserved in newly implanted adults with partial deafness (considerable low frequency acoustic hearing profiles with severe-to-profound high frequency sensorineural hearing loss) using the HiResolution™ 90K™ Advantage cochlear implant with the HiFocus™ Mid-Scala electrode to support the development of electro-acoustic stimulation technology (EAS). Type: Interventional Start Date: Apr 2014 |
Promoting Colorectal Cancer Screening in Rural Emergency Departments
University of Kentucky
Colorectal Cancer
This trial will compare the effects of a culturally targeted intervention designed to assist
participants to identify and overcome individual barriers to colorectal cancer (CRC) and to
promote CRC screenings using motivational interviewing (Ml) delivered by a lay health advisor... expand
This trial will compare the effects of a culturally targeted intervention designed to assist participants to identify and overcome individual barriers to colorectal cancer (CRC) and to promote CRC screenings using motivational interviewing (Ml) delivered by a lay health advisor (LHA) compared to the current standard-of-care (distribution of a brochure describing CRC screening services offered by the hospital) on CRC screening compliance. Type: Interventional Start Date: Nov 2014 |
Understanding the Impact of Critical Illness on Falls Risk - a 12 Month Observational Study
University of Melbourne
Critical Illness
Understanding the Impact of Critical Illness on Falls Risk - a 12 Month Observational Study
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Understanding the Impact of Critical Illness on Falls Risk - a 12 Month Observational Study Type: Observational [Patient Registry] Start Date: Apr 2017 |